Thanks to Andréa for this MythTickle:
After a gap of not quite a year, the GoComics feed for Randolph Itch restarted. This one for 2022 March 7 seems to be the first cartoon in the cycle.
Which doesn’t make its meaning clear!
Just for interest, here are the next two cartoons in the cycle. Not as puzzling, maybe.
Looks like somebody’s been hitting that Welsh rarebit too close to bedtime!