Thanks much to chemgal, who has done all of the work of writing up the background and the CIDU question:

I really don’t get the April 7th Arlo & Janis, though it is in the middle of a series, so maybe tomorrow’s comic will explain it. For those who don’t read A&J regularly, the set-up to this point is that we’re seeing a flashback to when A&J met while she was taking art and he was working at the bookstore, and in the previous couple of comics, Janis slowed things down:

So my question is, what does “college town” have to do with anything here?

And an auxiliary question from me: Who else thinks Arlo’s moustache is the most annoying thing ever?

No, not from the Non Sequitur strip. That’s instead a characterization of this Arlo and Janis.

Not “sent in by” but still suggested by someone: commenter Tyge at GoComics said “This looks like a CIDU to me. 8^( ”

Total mystery. But yields immediately to getting a definition .

Our first A&J is from Mark M, who asks “Why does she feel that way at 3 o’clock?  Is this an example of an overreaction as CIDU Bill used to talk about?”

Possibly the discussion of overreaction Mark is thinking of included this thread.

(For a quick factual overview of “sleeping pills”, here is a web excerpt from a book by Wallace B. Mendelson, MD.)

And Jack Applin sent in another puzzling A&J. He says: “I do not understand this Arlo & Janis. Arlo speaks of the expression bone in her teeth, explaining how it comes from the bow wave of a fast-moving boat. OK, sure. However, the way the he says it implies that this is a standard expression, used in other contexts. “

“I might say Do you know where the expression ‘read the riot act’ came from?, because people use that without reference to the 1714 act of the Parliament of Great Britain, e.g., when their mother caught them coming home late.. Who says bone in her teeth without referring to a bow wave?”

From Le Vieux Lapin, who says: I’m not a sports guy, so I looked “Cupcake Week” up on the web, and I still don’t get it.

I didn’t know what “cupcake week” means either, but did have a plausible guess.  The comments (yeah, I had to look) gave a more complete explanation, however, that I would not have arrived at by guesswork and reasoning from the guesses… So I’d call that a legit CIDU!