This was posted on another list, and while the comic itself isn’t a CIDU, I find Lucy’s comment opaque:

Why is she saying “This time will be so differ[ent]”? It’s always the same for her, at least usually!

The mashup is apparently from the 2011 book The Romita Legacy, about the career of comic book artist John Romita Sr.: https://www.hoopladigital.com/comic/the-romita-legacy-tom-spurgeon/13304781