Yes, this comic is often confusing, but to me this one should be understandable (except the life cycle of caterpillars is often too short; 7 to 14 days is common). Is this some mythical creature?
My first thought was that this was part of a series, but this is the previous one, which has no connection (and could be treated as a CIDU in its own right). Guau translates as wow or woof.
Or, maybe the next one is part of a series. But no, although this one’s more straightforward.
The artist lives in Mexico City, if that explains any of the cultural references.
Comics I Don't Understand 
The second one is easy enough. That’s Supergirl and, presumably, Krypto. He’s bounding over a cliff with a ball, but they’re under a red sun, which means no superpowers. It’s not funny, but I understand everything that’s going on.
Is that supposed to be Frida Kahlo in the first one? I’m just going by the eyebrows. If so, does that help anyone to understand it?
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Given the Mexico connection, I think the first one is a Frida Kahlo connection, as DemetriosX has it. The caterpillar is in love with her monobrow.
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The second one was easy. The third “straightforward” one, though: no idea.
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Ah, no superpowers under a red sun. I need to brush up on my superhero knowledge.
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Also, if it helps, “Guau” is Spanish onomatopoeia for a dog’s bark (“bow wow”).
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zbicyclist: Current lore has it that Supergirl is a party animal who takes a rocket to red sun worlds so she can get drunk. See the recent graphic novel, Supergirl: Woman of Tomorrow, the basis for this summer’s movie.
Kryptonians have no superpowers under red or green suns. They are vulnerable to green, red, and gold kryptonite, and magic. (Jim, the scary geek from Geeksville, once performed a close-up card trick in front of a Superman parody, who collapsed at his feet. “Magic. Dumb weakness.”)
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The cartoonist, Guillermo Saldaña, has answered emails before about individual strips although he may not want to do that on a regular basis.
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The caterpilar apparently thinks the guy’s hair is…a bunch of caterpilars.
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There are no “suns” that would be perceived as green by humans. Of course, Kryptonians aren’t exactly human.
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In Silver Age comics lore, green stars gave Earth humans super powers. But, as Brian says above, there were very, very few of them, so it almost never came up.
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“There are no “suns” that would be perceived as green by humans. Of course, Kryptonians aren’t exactly human.”
With the proviso that they can interbreed with Earth humans. Case in point, the current season of My Adventures With Superman.
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