Thanks to Targuman for this homonym-based OY. And for anyone who might not catch the almost-quotation, he offers these tips: See Mark 6:36 // Matt. 16:26.
The squirrel gives one popular musical association to this city. But some of us would go for “Stuck inside of Mobile with the Memphis blues again!”.
Panel four is definitely an OY (and the raccoon agrees).
Panel three is misinformation:
cross-species transmission is widespread.
See, for instance, here:
Panel two is borderline Op-Ed.
Panel one is just plain INSANE!