And what would the act of being incompatible look like?
The blonde isn’t a frequent character in this strip.
I find myself thinking of that Nat King Cole hit, “Unforgettable”, but with “Incompatible” substituted.
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The puzzlement is part of the joke, I think.
Basically, she’s calling herself and her boyfriend “incompatible”, which is usually a neutral term implying no fault on either side, then proceeding to complain that she hasn’t been able to identify any specific behavior on his part that would justify her opinion of their incompatibility.
Either she’s looking to break up but wants to be able to portray herself as the wronged party, or she just can’t justify breaking up without some sort of pretext she can point to.
Comics I Don't Understand 
The puzzlement is part of the joke, I think.
Basically, she’s calling herself and her boyfriend “incompatible”, which is usually a neutral term implying no fault on either side, then proceeding to complain that she hasn’t been able to identify any specific behavior on his part that would justify her opinion of their incompatibility.
Either she’s looking to break up but wants to be able to portray herself as the wronged party, or she just can’t justify breaking up without some sort of pretext she can point to.