This first one may not strictly count as CIDU, since in the end I do understand it. But it took a lot of work!
For this other one, the song quoted and the musician mentioned are easily verified to match up, even if not in your personal playlist. But …
… but I genuinely don’t get the part about “If you’re gonna sound like a Karen…” — there doesn’t seem to be enough basis to take that in the contemporary quasi-political sense of a denigrating term for a woman being fussy in a certain way. And without that, what is there for “sound like a Karen” to mean?
Comics I Don't Understand 
In the second strip, the girl’s point is precisely that the lyrics do not sound like the classic “Karen” meme; she is arguing that she would rather sound uplifting and nice, rather than fussy.
P.S. For the first strip, I cannot get the arithmetic to work. My first idea was 9:01:01 + 7:00:00 = 16:01:01, but that led nowhere. Since the solution has been left as a difficult exercise for the alert student, is there anyone out there who is alert enough to provide the answer?
It’s showing 9:11 and a 12 hour display adding 7 hours would show 4-1-1, the phone number for information.
I think the second one is simply what you note and dismiss as inadequate: if you have to sound like a Karen, sound like the liquid gold of a Karen Carpenter and not the shrieking buzzsaw of Karen Complainer. If you have to sound like an Otis sound like Otis Redding and not an Otis elevator.
I don’t get the first, though. 9-1-1 presumably relates to the US emergency number; do you have to add a minute to make it 9-1-2? If you then add seven hours is it 16-1-2 or 4-1-2 or 4-1-1? Probably nothing to do with adding anything to anything.
@Kilby: 16:01:01 in standard time is 4:01:01 PM, or 411, the number for directory assistance (“information”) in the US.
I too have no idea about the first one; I note that the clock in the background is nominally showing the time to be 9:11, so if the joke is that blue rabbit is somehow just clueless about how clocks work, I don’t see why they’d become less clueless in 7 hours… now, if it were 7 hours and 9 minutes, then you have another meme, in which while maybe you don’t get more information, you might just stop caring.
Kilby and Mark H, why are you going down to seconds? That’s what’s throwing you off. The very convincing answers that have been given are based simply in hours and minutes.
Kilby 1 and Narmitaj 3, your defense of the Karen dialogue leaves me unconvinced. (Though “Karen Complainer” is an excellent coinage!)
It remains out-of-the-blue, with no basis for introducing the first Karen instance.
I definitely remember when “Directory Assistance” became the official terminology. (No, I don’t mean I can tell you what year it was..) And before that it was a standard joke for someone to call Information and expect to have non-telephonic questions answered. (Just as public Information Booths in busy places would treat questions on topics beyond locations of stores / features / trains.) Perhaps they did seriously get bothered by that, and it had something to do with the renaming.
In any case, the local short-dial number for Directory Assistance or Information was, and probably still is, 411.
There was an Internet-speech trend a few years ago to say things like “what is the four one one on that?” to ask for the details or specifics of something.
Before 411, you would dial the operator (or before dial phones, just pick up) and ask for “Information, please.” That inspired a radio show, “Information, Please,” from the 1930’s to about 1950. Listeners would write in questions on any topic and the panelists would do their best to answer the questions. I wonder if this led to the idea that you could pick up the phone, ask for “Information, please” and get answers on any topic.
Unlike Dana K I find the Karen explanation completely convincing. The concept of a Karen doesn’t have to be previously introduced for it to work.
Belated thanks to all for the (very simple) “411” answer. I’ve gotten so used to 24-hour time that I simply don’t think in AM & PM any more.
P.S. @ Dana (6) – The reason I went to seconds is because of the unfortunate interpunction (using two hyphens) in the first panel. If the dialog had cited the time properly as “9:11” (instead of “9-1-1”), then the whole strip would have been much easier to understand.
If he’d understood it was time it would have been properly punctuated – since he just saw the numbers that’s what he “said”. It took me some math plus remembering to convert to 12-hour time, but I did finally get it (before reading the comments).
Kilby – The only clock in our house which is on 24 hour time is my alarm clock (our main alarm clock as he rarely needs to get up early any longer and when he does – for whatever reason he needs to get up, so do I, so we only set my alarm clock). I keep it as a 24 hour clock so that when I jump out of bed to check that it is set to the correct time, I don’t have to jump out of bed a second time to check that it set to the right 10:00 as the other one would be 22:00. Since it a bedroom clock, generally when we are in there (as we go to bed after midnight – to understate how late it is) it is almost always on the original 1 am to noon part of the day when we are checking what time it is. He keeps his clock on a 12 hour time setup.
I have a microwave clock that I’ve complained about here before that I wish would be 24 hour, only because I’m anal that way: every time there’s a brief interruption of power, the clock needs to be reset. For some stupid reason, the clock has a “pm” indicator (but no “am”!), as if anyone really cares — nothing done on the microwave is going to need the differentiation — but it has it, and invariably I set it wrong, I don’t know how it gets set, but a few days after I set it, I notice it’s telling me it’s 10 pm in the morning. (I’d say a significantly more than 50% portion of the time I reset it I set it wrong, which either means Murphy is in full strength, or the power interruptions happen more in the pm than am, or vice versa.) As I say, there’s nothing on the microwave that needs a differentiation between am/pm, it just bothers me to see it set wrong, but not enough for me to dig out the manual, or figure out the totally non-intuitive way I’d need to set it right. So I wish I could just punch in the 24 hour time, and it would be right, 100% of the time.