Boise Ed sends this in as a “CIDU, sort of”: “Why is this funny? It sounds like a great idea. Unfortunately, the drawing makes them way too thick for Oreos. They look more like ice-cream sandwiches. Yum.”
There do seem to be such a thing as giant Oreos, and a suggested use is ice cream sandwiches.
Comics I Don't Understand 
Maryland is known for Blue Crabs, and one way to prepare crabs is to boil them in water into which a bag of spices (sometimes called a crab boil) is placed, and Baltimore is a city in Maryland, and Baltimore’s baseball team is the Orioles.
Or “Baltimoreos” for short.
An Oreo is a type of chocolate sandwich cookie and an Oriole is a type of bird. The baseball team in the city of Boston Massachusetts is sometimes called “The Boston Orioles”. Boston is located next to the Atlantic Ocean and has a thriving seafood industry which includes crabs.
I don’t personally think a chocolate cookie would pair well with seafood but since Massachusetts allows their residents to use recreational cannabis it would not surprise me they also do this.
I think the joke is that crab flavored oreos sound gross.
Big oreos are fine. Big oreos dipped in crab meat and old bay seasoning? No thanks.
It’s also a pun on their baseball team, the Baltimore Oriels (named after an orange bird).
@Anonymous: Your suggestion that Boston’s baseball team is known as the Boston Orioles seems to be overly influenced by AI.
AI is the only way to explain that absolute nonsense of a comment lol As a Red Sox fan for more than 30 years, I can safely inform you that the Boston baseball team has never been known as the Orioles, and of course the comic is about Baltimore, not Boston.
In addition to giant Oreos, there are also pre-made Oreo-branded ice cream sandwiches that are about the size of those “Baltimore Oreos”.
Shouldn’t his “pipe” be in the front of his pants?
Back in the 1970’s there was a cheesecake stand in Harvard Square, not far from Boston, that sold what they called “Baltimore Oreos”. But they were actually Whoopie Pies. A Whoopie Pie is about four inches in diameter and consists of two somewhat dome-shaped pieces of chocolate cake with a cremey (no cream therefore not creamy) filling. The term “Whoopie Pie” is not registered or copyrighted so I know of no reason why they didn’t just call them that. As far as I know, the term “Oreo” is registered and copyrighted so I know of no way they could have called them that but they did. The Baltimore Orioles are a rival to the Boston Red Sox, both in the American League East, so there is no particular love for Baltimore in Boston, although not as much hatred as for New York City.
Rolling an ice cream cookie sandwich in Old Bay Seasoning and calling it a Baltimore Oreo makes some sense, at least on paper. Making Whoopie Pies near Boston and calling them Baltimore Oreos makes no sense.
Often crab boil mixes involve whole spices like coriander and black pepper. They aren’t really designed to be eaten. Spice mixes like Old Bay Seasoning would make more sense in this context.
MiB (9): So, before opening the stand each day, did the guy spend hours making whoopie?
The Baltimore Oreos pun was good, but old hat (or cap). My mistake was assuming everyone already knew about the Orioles.
Crab boil is new to me, but makes sense. I still think it might make a tasty ornament for an ice-cream sandwich (a thick one, like Klondike or It’s-It).
A nit pick… to me, at least, the man in the picture seems surprised by what she is saying, but he’s already taken a bite. I figure he would have known something was ‘fishy’ before she commented.
Boise Ed (11): If they guy did spend hours making whoopie, he didn’t admit to it, or he called it making baltimore.
Just today I stopped at a hot dog stand in New Hampshire, and they had whoopie pies displayed but not labeled with any name at all.